Upadacitinib [1310726-60-3]
Katalog-Nummer HY-19569-100mg
Size : 100mg
Marke : MedChemExpress
Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Upadacitinib Chemische Struktur
CAS. Nr. : 1310726-60-3
This product is a controlled substance and not for sale in your territory.
Based on 12 publication(s) in Google Scholar
Other Forms of Upadacitinib:
- Upadacitinib-15N,d2 In-stock
- Upadacitinib tartrate tetrahydrate Angebot einholen
- Upadacitinib-d5 Angebot einholen
Alle JAK Isoform-spezifische Produkte anzeigen:
Beschreibung |
Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research[1][2]. |
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IC50 & Target[1] |
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In Vitro |
In biochemical assays, Upadacitinib is 74-fold more selective for JAK-1 than for JAK-2 (which is involved in erythropoiesis) and 58-fold more selective for JAK-1 than for JAK-3 (which is involved in immunosurveillance)[1]. The enhanced selectivity of Upadacitinib for JAK-1 over JAK-2 and JAK-3 may offer an improved benefit–risk profile in patients with RA range[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Upadacitinib (0.1-10 mg/kg; oral gavage; twice a day for 10 days) demonstrates efficacy in rat arthritis models[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Klinische Studie |
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Molekulargewicht |
380.37 |
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Formel |
C17H19F3N6O |
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CAS. Nr. |
1310726-60-3 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
O=C(N1C[C@@H](CC)[C@@H](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 100 mg/mL (262.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : < 0.1 mg/mL (insoluble) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.98% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.6290 mL | 13.1451 mL | 26.2902 mL | 65.7255 mL |
5 mM | 0.5258 mL | 2.6290 mL | 5.2580 mL | 13.1451 mL | |
10 mM | 0.2629 mL | 1.3145 mL | 2.6290 mL | 6.5725 mL | |
15 mM | 0.1753 mL | 0.8763 mL | 1.7527 mL | 4.3817 mL | |
20 mM | 0.1315 mL | 0.6573 mL | 1.3145 mL | 3.2863 mL | |
25 mM | 0.1052 mL | 0.5258 mL | 1.0516 mL | 2.6290 mL | |
30 mM | 0.0876 mL | 0.4382 mL | 0.8763 mL | 2.1908 mL | |
40 mM | 0.0657 mL | 0.3286 mL | 0.6573 mL | 1.6431 mL | |
50 mM | 0.0526 mL | 0.2629 mL | 0.5258 mL | 1.3145 mL | |
60 mM | 0.0438 mL | 0.2191 mL | 0.4382 mL | 1.0954 mL | |
80 mM | 0.0329 mL | 0.1643 mL | 0.3286 mL | 0.8216 mL | |
100 mM | 0.0263 mL | 0.1315 mL | 0.2629 mL | 0.6573 mL |
Upadacitinib Related Classifications
- Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
- JAK