General Info
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.123ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This CAMK2g Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
Information
| Gene Symbol: | Camk2g |
| Gene ID: | 171140 |
| Uniprot ID: | KCC2G_RAT |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
Description
| Tissue Specificity | |
| Post Translational Modifications | Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit GammaCam Kinase Ii Subunit GammaCamk-Ii Subunit Gamma |
| Database Links | Reactome: R-RNO-3371571Reactome: -RNO-399719Reactome: -RNO-438066Reactome: -RNO-5578775Reactome: -RNO-5673000Reactome: -RNO-5673001Reactome: -RNO-877300Reactome: -RNO-936837 |
| Cellular Localisation | Sarcoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative ELISA Names | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Gamma ELISA kitCam Kinase Ii Subunit Gamma ELISA kitCamk-Ii Subunit Gamma ELISA kitCamk2g ELISA kit |
| output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance