ALS16975 | GJA1 / CX43 / Connexin 43 Antibody (aa340-390) Biotrend

Product Information
Application Applications Legend: WB=Western Blot IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin-embedded Sections) IHC-F=Immunohistochemistry (Frozen Sections) IF=Immunofluorescence FC=Flow Cytopmetry IC=Immunochemistry ICC=Immunocytochemistry E=ELISA IP=Immunoprecipitation DB=Dot Blot CHIP=Chromatin Immunoprecipitation FA=Fluorescence Assay IEM=Immunoelectronmicroscopy EIA=Enzyme Immunoassay	WB, IHC-P, IF
Primary Accession	P17302
Other Accession	2697
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Calculated MW	43008 Da
Dilution	IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000),

Additional Information
Gene ID	2697
Other Names	GJA1, Connexin-43, DFNB38, Connexin 43, Gap junction alpha-1 protein, GJAL, HSS, Gap junction protein alpha 1, ODDD, ODD, AVSD3, CX43, HLHS1, ODOD, SDTY3
Target/Specificity	Human GJA1 / Connexin 43
Reconstitution & Storage	PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Precautions	GJA1 / CX43 / Connexin 43 Antibody (aa340-390) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	GJA1
Synonyms	GJAL
Function	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
Cellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum {ECO:0000250\|UniProtKB:P23242}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. {ECO:0000250\|UniProtKB:P23242}
Tissue Location	Expressed in the heart and fetal cochlea.

GJA1 / CX43 / Connexin 43 Antibody (aa340-390)