Colchicine [64-86-8]
Katalog-Nummer HY-16569-500mg
Size : 500mg
Marke : MedChemExpress
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.
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Colchicine Chemische Struktur
CAS. Nr. : 64-86-8
This product is a controlled substance and not for sale in your territory.
Based on 35 publication(s) in Google Scholar
Other Forms of Colchicine:
- Colchicine-d6 Angebot einholen
- Colchicine-d3 Angebot einholen
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Colchicine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 15;2020:9173530. [Abstract]
- Colchicine plays an antipyroptosis role by inhibiting intracellular oxidative stress. HUVECs are treated for 10 or 24 h with different doses of Colchicine (0-10 nM) in the presence of cholesterol crystal (0.5 mg/mL). Intracellular ROS level is detected using a DCFH-DA probe. JC-1 Staining Kit is used for the detection of mitochondrial membrane potential.
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Colchicine purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 15;2020:9173530. [Abstract]
- Colchicine alleviates NLRP3 inflammasome activation relevant in pyroptosis. HUVECs are treated for 24 h with different doses of Colchicine (0-10 nM) in the presence of cholesterol crystal (0.5 mg/mL. Western blotting Is dedicated to examine the protein expression levels of NLRP3, ASC-1, procaspase-1, caspase-1, IL-18, and IL-1β. Colchicine treatment significantly blocks NLRP3 signal activity. Colchicine significantly inhibits CC-induced mRNA and protein expression of IL-18 and IL-1β, particularl
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Colchicine purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta. 2018 May;1862(5):1134-1147. [Abstract]
- CS1 and Colchicine (Col) induce the phosphorylation of H1 (T18) and H3 (S29) as detected by western blotting.