Bruceantin [41451-75-6]
Katalog-Nummer HY-N0840-1mg
Size : 1mg
Marke : MedChemExpress
Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.
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Bruceantin Chemische Struktur
CAS. Nr. : 41451-75-6
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Beschreibung |
Bruceantin(NSC165563) is first isolated from Brucea javanica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice. IC50 value: Target: anticancer Cell differentiation was induced and c-MYC was down-regulated, suggesting a mechanistic correlation between c-MYC down-regulation and induction of cell differentiation or cell death. Treatment of HL-60 and RPMI 8226 cell lines induced apoptosis, and this involved the caspase and mitochondrial pathways. Moreover, an in vivo study using RPMI 8226 human-SCID xenografts demonstrated that bruceantin induced regression in early as well as advanced tumors, and these significant antitumor responses were facilitated in the absence of overt toxicity. |
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Molekulargewicht |
548.58 |
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Formel |
C28H36O11 |
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CAS. Nr. |
41451-75-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C([C@@]1([C@H]([C@H](O)[C@]2(01)[C@]3(C4)C)O)[C@@]([C@H](C5=O)OC(/C=C(C)/C(C)C)=O)(01)[C@@]2([C@@](O5)(01)C[C@@]3(01)C(C)=C(O)C4=O)CO1)OC |
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Structure Classification |
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Initial Source |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 100 mg/mL (182.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.94% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.8229 mL | 9.1144 mL | 18.2289 mL | 45.5722 mL |
5 mM | 0.3646 mL | 1.8229 mL | 3.6458 mL | 9.1144 mL | |
10 mM | 0.1823 mL | 0.9114 mL | 1.8229 mL | 4.5572 mL | |
15 mM | 0.1215 mL | 0.6076 mL | 1.2153 mL | 3.0381 mL | |
20 mM | 0.0911 mL | 0.4557 mL | 0.9114 mL | 2.2786 mL | |
25 mM | 0.0729 mL | 0.3646 mL | 0.7292 mL | 1.8229 mL | |
30 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5191 mL | |
40 mM | 0.0456 mL | 0.2279 mL | 0.4557 mL | 1.1393 mL | |
50 mM | 0.0365 mL | 0.1823 mL | 0.3646 mL | 0.9114 mL | |
60 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7595 mL | |
80 mM | 0.0228 mL | 0.1139 mL | 0.2279 mL | 0.5697 mL | |
100 mM | 0.0182 mL | 0.0911 mL | 0.1823 mL | 0.4557 mL |