BODIPY FL prazosin [175799-93-6]
Katalog-Nummer HY-D1606-5mg
Size : 5mg
Marke : MedChemExpress
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes.
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BODIPY FL prazosin Chemische Struktur
CAS. Nr. : 175799-93-6
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen:
Beschreibung |
BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes[1][2][3]. |
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IC50 & Target[1] |
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In Vitro |
BODIPY FL prazosin (10 nM; 30 min at room temperature in 100 μl; COS-7 cells) shows Affinity of various α1-AR ligands with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molekulargewicht |
563.41 |
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Formel |
C28H32BF2N7O3 |
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CAS. Nr. |
175799-93-6 |
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Appearance |
Solid |
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Color |
Yellow to orange |
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Emission (Em) |
510 |
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Excitation (Ex) |
502 |
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SMILES |
O=C(CCC1=CC=C2C=C3C(C)=CC(C)=13[B+3]([F-])([N-]21)[F-])N4CCN(CC4)C5=NC6=C(C=C(C(OC)=C6)OC)C(N)=N5 |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 12.2 mg/mL (21.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
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Reinheit & Dokumentation |
Purity: 99.71% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.7749 mL | 8.8745 mL | 17.7491 mL | 44.3727 mL |
5 mM | 0.3550 mL | 1.7749 mL | 3.5498 mL | 8.8745 mL | |
10 mM | 0.1775 mL | 0.8875 mL | 1.7749 mL | 4.4373 mL | |
15 mM | 0.1183 mL | 0.5916 mL | 1.1833 mL | 2.9582 mL | |
20 mM | 0.0887 mL | 0.4437 mL | 0.8875 mL | 2.2186 mL |
BODIPY FL prazosin Related Classifications
- Metabolic Disease
- GPCR/G Protein Neuronal Signaling
- Adrenergic Receptor
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
BODIPY FL prazosin175799-93-6Adrenergic ReceptorBeta ReceptorCOS-7 cellsα1a-ARα1b-ARMEF3.8-BCRP cellsmolecular probeerythroleukemia cellsInhibitorinhibitorinhibit