Application
| WB, ICC |
---|---|
Primary Accession | A8MW95 |
Other Accession | NP_001277622.1 |
Host | Rabbit |
Reactivity | Human |
Clonality | Polyclonal |
Description | Rabbit Anti-Human Beclin 2 Polyclonal |
Target/Specificity | Predicted molecular weight at ~48.1kDa. Observed bands in the 50-55kDa range, varied by lysates. |
Other Names | BECN2 Antibody, Beclin-2 Antibody, Beclin-1 like protein 1 Antibody |
Immunogen | Synthetic peptide from the mid-protein of human Beclin 2 |
Purification | Peptide Affinity Purified |
Storage | -20ºC |
Storage Buffer | PBS, 50% glycerol, 0.09% sodium azide |
Shipping Temperature | Blue Ice or 4ºC |
Certificate of Analysis | A 1:1000 dilution of SPC-602 was sufficient for detection of Beclin2 on rat liver lysates using Goat anti-rabbit IgG:HRP as the secondary antibody. |
Cellular Localization | Cytoplasm |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Beclin 2 is a novel coiled-coil protein related to the autophagic Beclin 1 protein. It is thought to interact with Bcl-2, an anti-apoptotic protein, and is believed to function in autophagy. It has alson been found to mediate G protein-coupled receptro (GPCR) degradation (1).
References
1. He C., et al. (2013) Cell. 154(5): 1085-1099.
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Cat# ASM10491