Anti-SOCS3 antibody (175-225) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.50 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:50-1:200 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Immunogen Region:	175-225
Immunogen:	Synthetic peptide taken within amino acid region 175-225 on human SOCS3 protein.

Post Translational Modifications	Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name	Suppressor Of Cytokine Signaling 3 Socs-3 Cytokine-Inducible Sh2 Protein 3 Cis-3 Stat-Induced Stat Inhibitor 3 Ssi-3
Database Links	Reactome: R-HSA-1059683 Reactome: R-HSA-2586552 Reactome: R-HSA-6785807 Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-8849474 Reactome: R-HSA-8939242 Reactome: R-HSA-8951664 Reactome: R-HSA-909733 Reactome: R-HSA-912694 Reactome: R-HSA-982772 Reactome: R-HSA-983168
Alternative Antibody Names	Anti-Suppressor Of Cytokine Signaling 3 antibody Anti-Socs-3 antibody Anti-Cytokine-Inducible Sh2 Protein 3 antibody Anti-Cis-3 antibody Anti-Stat-Induced Stat Inhibitor 3 antibody Anti-Ssi-3 antibody Anti-SOCS3 antibody Anti-CIS3 antibody Anti-SSI3 antibody

Information sourced from Uniprot.org

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