General Info
Host: | Rabbit |
Applications: | ELISA/IHC/IP/WB |
Reactivity: | Human/Monkey |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-NME2 + NM23A is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | FITC |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.59 µg/µl |
Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:50-1:150 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | NME1 |
Gene ID: | 4830 |
Uniprot ID: | NDKA_HUMAN |
Description
Tissue Specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. |
Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. |
Protein Name | Nucleoside Diphosphate Kinase A Ndk A Ndp Kinase A Granzyme A-Activated Dnase Gaad Metastasis Inhibition Factor Nm23 Nm23-H1 Tumor Metastatic Process-Associated Protein |
Database Links | Reactome: R-HSA-499943 Reactome: R-HSA-9748787 Reactome: R-HSA-9755088 |
Cellular Localisation | Cytoplasm Nucleus Cell-Cycle Dependent Nuclear Localization Which Can Be Induced By Interaction With Epstein-Barr Viral Proteins Or By Degradation Of The Set Complex By Gzma |
Alternative Antibody Names | Anti-Nucleoside Diphosphate Kinase A antibody Anti-Ndk A antibody Anti-Ndp Kinase A antibody Anti-Granzyme A-Activated Dnase antibody Anti-Gaad antibody Anti-Metastasis Inhibition Factor Nm23 antibody Anti-Nm23-H1 antibody Anti-Tumor Metastatic Process-Associated Protein antibody Anti-NME1 antibody Anti-NDPKA antibody Anti-NM23 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance