Alzheimer Precursor Protein A4

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer's Disease. The principle component of this extracellular amyloid is beta/A4, a 4kD peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins are currently under investigation.||Applications:|Suitable for use in Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.||Recommended Dilutions:|Immunohistochemistry: 5-10ug/ml on 4% paraformaldehyde/15% picric acid perfused and fixed rat spinal cord. Also good for paraffin-embeddedd tissues at 1:10- 1:20.|Western Blot: 10ug/ml under reducing conditions. |Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.