Alpha-Synuclein / SNCA (96-140) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Predicted MW	5.217 kDa
Purity	>95%
Presentation	Purified
Buffer	Presentation State: Purified
Reference Data
RefSeq	NP_000336
Locus ID	6622
UniProt ID	P37840
Cytogenetics	4q22.1
Synonyms	NACP; PARK1; PARK4; PD1
Summary	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Parkinson's disease