AICAR [2627-69-2]
Katalog-Nummer T1477-50mg
Size : 50mg
Marke : TargetMol
Contact local distributor :
Telefonnummer : +1 850 650 7790
AICAR
Contact us for more batch information
Purity:99.71%
Resource Download
COA HNMR LCMS
AICAR
Catalog No. T1477Cas No. 2627-69-2
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | |
|---|---|
| 25 mg | |
| 50 mg | |
| 1 mL x 10 mM (in DMSO) |
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. |
| Cell Research | Acadesine is added to K562 cell lines or primary cells (103 CD34+ cells/mL) growing in semisolid methyl cellulose medium. MethoCult H4100 or H4236 are used for cell lines and primary CD34+ cells respectively. Colonies are detected after 10 days of culture by adding 1 mg/mL of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reagent and are scored by Image J quantification software. (Only for Reference) |
| Alias | NSC105823, AICA Riboside, Acadesine, AICAR (Acadesine) |
| Molecular Weight | 258.23 |
| Formula | C9H14N4O5 |
| Cas No. | 2627-69-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
| Solubility Information | H2O: 19.4 mg/mL (75 mM) DMSO: 19.4 mg/mL (75 mM) | ||||||||||
Solution Preparation Table | |||||||||||
H2O
| |||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg,each 
animal weighs 20 g, and the dosage volume is 100 μL. A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify.
Dose Conversion
You can also refer to dose conversion for different animals. More
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Keywords
Yes-associated proteinAutophagyinhibitAMPKAICARMitophagyNSC-105823Endogenous MetaboliteNSC 105823AMP-activated protein kinaseMitochondrial AutophagyYAPInhibitor