α-Cyano-4-hydroxycinnamic acid [28166-41-8]
Katalog-Nummer HY-107641-50mg
Size : 50mg
Marke : MedChemExpress
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications.
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α-Cyano-4-hydroxycinnamic acid Chemische Struktur
CAS. Nr. : 28166-41-8
This product is a controlled substance and not for sale in your territory.
Based on 2 publication(s) in Google Scholar
Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen:
Beschreibung |
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs). α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2]. |
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In Vitro |
α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) inhibits monocarboxylates transport such as lactate and pyruvate[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molekulargewicht |
189.17 |
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Formel |
C10H7NO3 |
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CAS. Nr. |
28166-41-8 |
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Appearance |
Solid |
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Color |
Light yellow to yellow |
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SMILES |
O=C(O)/C(C#N)=C/C1=CC=C(O)C=C1 |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 250 mg/mL (1321.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 1 mg/mL (5.29 mM; ultrasonic and warming and heat to 60°C) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 99.98% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 5.2863 mL | 26.4313 mL | 52.8625 mL | 132.1563 mL |
5 mM | 1.0573 mL | 5.2863 mL | 10.5725 mL | 26.4313 mL | |
DMSO | 10 mM | 0.5286 mL | 2.6431 mL | 5.2863 mL | 13.2156 mL |
15 mM | 0.3524 mL | 1.7621 mL | 3.5242 mL | 8.8104 mL | |
20 mM | 0.2643 mL | 1.3216 mL | 2.6431 mL | 6.6078 mL | |
25 mM | 0.2115 mL | 1.0573 mL | 2.1145 mL | 5.2863 mL | |
30 mM | 0.1762 mL | 0.8810 mL | 1.7621 mL | 4.4052 mL | |
40 mM | 0.1322 mL | 0.6608 mL | 1.3216 mL | 3.3039 mL | |
50 mM | 0.1057 mL | 0.5286 mL | 1.0573 mL | 2.6431 mL | |
60 mM | 0.0881 mL | 0.4405 mL | 0.8810 mL | 2.2026 mL | |
80 mM | 0.0661 mL | 0.3304 mL | 0.6608 mL | 1.6520 mL | |
100 mM | 0.0529 mL | 0.2643 mL | 0.5286 mL | 1.3216 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Cyano-4-hydroxycinnamic acid Related Classifications
- Membrane Transporter/Ion Channel
- Monocarboxylate Transporter