TNFRSF1A (full length) Mouse Monoclonal Antibody [Clone ID: H398]
CAT#: SM1185LE
TNFRSF1A (full length) mouse monoclonal antibody, clone H398, Low Endotoxin
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Product Data | |
Clone Name | H398 |
Applications | FC, FN, IHC, IP |
Recommended Dilution | Flow cytometry. Immunoprecipitation. Immunohistochemistry (paraffin sections). Immunohistochemistry (frozen sections). Functional application: blocking. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Recombinant full length human CD120a |
Specificity | This antibody recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta. |
Formulation | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Low Endotoxin State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | tumor necrosis factor receptor superfamily member 1A |
Database Link | |
Background | CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. |
Synonyms | Tumor necrosis factor receptor 1, TNF-R1, TNF-RI, TNFR-I, p55, p60, Tnfrsf1a |
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