TAZ Polyclonal Antibody, PE-Cy7 Conjugated
Cat# bs-12367R-PE-Cy7
Size : 100ul
TAZ Polyclonal Antibody, PE-Cy7 Conjugated
Applications
Reactivity
Overview | |
Catalog # | bs-12367R-PE-Cy7 |
Product Name | TAZ Polyclonal Antibody, PE-Cy7 Conjugated |
Applications | WB, FCM |
Reactivity | Human, Mouse, Rat |
Specifications | |
Conjugation | PE-Cy7 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human TAZ |
Immunogen Range | 1-100/400 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 25937 |
Swiss Prot | Q9GZV5 |
Subcellular location | Cytoplasm, Nucleus, Cell membrane |
Synonyms | TAZ; WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motif; WWTR1 |
Background | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
Application Dilution | |
WB | 1:300-5000 |
FCM | 1:20-100 |