ALS10547 | RORB / ROR Beta Antibody (Ligand-binding Domain) Biotrend

Anti-RORB / ROR Beta antibody IHC of human Skin, Melanoma.
Anti-RORB / ROR Beta antibody IHC of human Lung, Small Cell Carcinoma.

Product Information
Application Applications Legend: WB=Western Blot IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin-embedded Sections) IHC-F=Immunohistochemistry (Frozen Sections) IF=Immunofluorescence FC=Flow Cytopmetry IC=Immunochemistry ICC=Immunocytochemistry E=ELISA IP=Immunoprecipitation DB=Dot Blot CHIP=Chromatin Immunoprecipitation FA=Fluorescence Assay IEM=Immuno electron microscopy EIA=Enzyme Immunoassay	IHC-P
Primary Accession	Q92753
Reactivity	Human, Mouse, Rabbit, Hamster, Monkey, Chicken, Sheep, Horse, Bovine, Dog
Host	Rabbit
Clonality	Polyclonal
Calculated MW	53220 Da
Dilution	IHC-P (5 µg/ml)

Additional Information
Other Names	Nuclear receptor ROR-beta, Nuclear receptor RZR-beta, Nuclear receptor subfamily 1 group F member 2, Retinoid-related orphan receptor-beta, RORB, NR1F2, RZRB
Target/Specificity	Human ROR Beta. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage	Long term: -70°C; Short term: +4°C
Precautions	RORB / ROR Beta Antibody (Ligand-binding Domain) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	RORB
Synonyms	NR1F2, RZRB
Function	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).
Cellular Location	Nucleus, nucleoplasm
Volume	50 µl

Citations (0)

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