Reticulon 4 Polyclonal Antibody, PE-Cy7 Conjugated
Cat# bs-1315R-PE-Cy7
Size : 100ul
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Reticulon 4 Polyclonal Antibody, PE-Cy7 Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-1315R-PE-Cy7 |
| Product Name | Reticulon 4 Polyclonal Antibody, PE-Cy7 Conjugated |
| Applications | WB |
| Specificity | Based on the location of the target sequence this antibody will recognize all isoforms(Nogo-A, Nogo-B, and Nogo-C). |
| Reactivity | Human, Mouse |
| Predicted Reactivity | Rat, Dog, Sheep |
| Specifications | |
| Conjugation | PE-Cy7 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from Mouse Reticulon 4 |
| Immunogen Range | 251-357/357 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 68585 |
| Swiss Prot | Q99P72 |
| Subcellular location | Cytoplasm, Cell membrane |
| Synonyms | Reticulon-4; Rtn4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; euroendocrine-specific protein C homolog; RTN-x; Reticulon-5; RTN 4A; Nogo-A; RTN-xL; RTN 4B; ASY; Nogo-B; RTN-xS; Foocen-M; RTN 4C; Nogo-C; Foocen-S; RTN4-B2; Rtn-T |
| Background | Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The reticulon protein is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon 4 regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing. |
| Application Dilution | |
| WB | 1:300-5000 |