The PAK4 FISH probe is designed to hybridize to the PAK4 gene and is primarily used for detecting amplifications and deletions associated with the gene. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe can be labeled in one of five colors. Each probe is sold in a 20 test kit (approximately 20 slides - 22x22 mm area) and includes hybridization buffer. Please note that due to design optimizations, are subject to change.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Gene Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Details

Gene Symbol: PAK4

Gene Name: P21 (RAC1) Activated Kinase 4

Chromosome: CHR19: 39616419-39670046

Locus: 19q13.2

References

Customer Publications

There are currently no FISH related publications for this gene.

Product Details

Product: PAK4 FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: PAK4-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping