OF-C4-Deg-Lin [2383003-60-7]
Cat# HY-148855-25mg
Size : 25mg
Brand : MedChemExpress
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA.
For research use only. We do not sell to patients.
OF-C4-Deg-Lin Chemical Structure
CAS No. : 2383003-60-7
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
OF-C4-Deg-Lin is an ionizable lipid with varied linker lengths. OF-C4-Deg-Lin can be used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA and mRNA[1]. |
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Molecular Weight |
1594.49 |
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Formula |
C100H176N4O10 |
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CAS No. |
2383003-60-7 |
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Unlabeled CAS |
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Appearance |
Oil |
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Color |
Colorless to light yellow |
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SMILES |
CCCCC/C=C\C/C=C\CCCCCCCC(OCCCCN(CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCCC[C@H]1C(N[C@H](C(N1)=O)CCCCN(CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (62.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: ≥95.0% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 0.6272 mL | 3.1358 mL | 6.2716 mL | 15.6790 mL |
5 mM | 0.1254 mL | 0.6272 mL | 1.2543 mL | 3.1358 mL | |
10 mM | 0.0627 mL | 0.3136 mL | 0.6272 mL | 1.5679 mL | |
15 mM | 0.0418 mL | 0.2091 mL | 0.4181 mL | 1.0453 mL | |
20 mM | 0.0314 mL | 0.1568 mL | 0.3136 mL | 0.7839 mL | |
25 mM | 0.0251 mL | 0.1254 mL | 0.2509 mL | 0.6272 mL | |
30 mM | 0.0209 mL | 0.1045 mL | 0.2091 mL | 0.5226 mL | |
40 mM | 0.0157 mL | 0.0784 mL | 0.1568 mL | 0.3920 mL | |
50 mM | 0.0125 mL | 0.0627 mL | 0.1254 mL | 0.3136 mL | |
60 mM | 0.0105 mL | 0.0523 mL | 0.1045 mL | 0.2613 mL |
OF-C4-Deg-Lin Related Classifications
- Biochemical Assay Reagents
- Metabolic Enzyme/Protease
- Liposome