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> MRS 1754 [264622-58-4]

MRS 1754 [264622-58-4]

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Cat# T16140-10mg

Size : 10mg

Brand : TargetMol

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MRS 1754

MRS 1754
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Purity:97.48%
Resource Download
COA LCMS HPLC HNMR

MRS 1754

Catalog No. T16140Cas No. 264622-58-4
MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack Size
1 mg
5 mg
10 mg
25 mg
50 mg
100 mg
1 mL x 10 mM (in DMSO)

Product Introduction

Bioactivity
Description
MRS 1754 is a selective antagonist radioligand for the A2B adenosine receptor. It has a very low affinity for A1 and A3 receptors of both humans and rats.
In vitro
The Ki value for displacement of [3H]MRS 1754 binding to human A2B receptors expressed in HEK-293 cell membranes is 1.45±0.21 nM. The most effective displacer of [3H]MRS 1754 binding is MRS 1754. .
Chemical Properties
Molecular Weight486.52
FormulaC26H26N6O4
Cas No.264622-58-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 15 mg/mL (30.83 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0554 mL10.2771 mL20.5541 mL102.7707 mL
5 mM0.4111 mL2.0554 mL4.1108 mL20.5541 mL
10 mM0.2055 mL1.0277 mL2.0554 mL10.2771 mL
20 mM0.1028 mL0.5139 mL1.0277 mL5.1385 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Adenosine ReceptorMRS1754InhibitorP1 receptorMRS-1754inhibitMRS 1754