Human SIRT2 activation kit by CRISPRa

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Cat# GA107924

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Human SIRT2 activation kit by CRISPRa

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SKU

GA107924

SIRT2 CRISPRa kit - CRISPR gene activation of human sirtuin 2

Datasheet SDS

Find the corresponding CRISPRi Inhibitor Kit

2 Weeks*

Specifications
Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol	SIRT2
Locus ID	22933
Components	GA107924G1, SIRT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107924G2, SIRT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107924G3, SIRT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping	Ambient
Reference Data
RefSeq	NM_001193286, NM_012237, NM_030593, NR_034146
UniProt ID	Q8IXJ6
Synonyms	SIR2; SIR2L; SIR2L2
Summary	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]

Product Manuals
CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi) Manual
FAQs
FAQ for CRISPR Products
SDS
SDS for GA107924

Gene Expression Resources
4-min CRISPR Quick-Learning Video Video Protocol: Gene Knockout with CRISPR Kit Frequently Asked Questions on CRISPR Webinar from Cell: Expanding CRISPR Toolbox CRISPR Knockout kit manual CRISPR vector manual CRISPR Trangene Knockin at AAVS1 and ROSA26 loci manual CRISPR activation (CRISPRa) and CRISPR interference (CRISPRi) manual HA-Tagging Validation Data qPCR manual Mycoplasma Detection Kit w/ IAC Video Protocol: MycoTrack^TM

SKU	Description	Size
KN200191	SIRT2 - human gene knockout kit via CRISPR, HDR mediated	1 kit
KN200191BN	SIRT2 - human gene knockout kit via CRISPR, HDR mediated	1 kit
KN200191LP	SIRT2 - human gene knockout kit via CRISPR, HDR mediated	1 kit
KN200191RB	SIRT2 - human gene knockout kit via CRISPR, HDR mediated	1 kit
KN400191	SIRT2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated.	1 kit

Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.