Specifications

Product Data
Applications	IHC
Recommended Dilution	IHC: 25-100 Positive control: Human renal cancer Predicted cell location: Cytoplasm, Cell membrane
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 24-145 amino acids of human glucagon-like peptide 1 receptor
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Gene Name	glucagon like peptide 1 receptor
Database Link	NP_002053 Entrez Gene 14652 MouseEntrez Gene 25051 RatEntrez Gene 2740 Human UniProt ID P43220
Background	The glucagon-like peptide 1 receptor (GLP1R) is a human gene which resides on chromosome 6.The protein encoded by this gene is a member of the glucagon receptor family of G protein-coupled receptors. GLP1R binds specifically the glucagon-like peptide-1 (GLP1) and has much lower affinity for related peptides such as the gastric inhibitory polypeptide and glucagon. GLP1R is known to be expressed in pancreatic beta cells. Activated GLP1R stimulates the adenylyl cyclase pathway which results in increased insulin synthesis and release of insulin. Consequently GLP1R has been suggested as a potential target for the treatment of diabetes.
Synonyms	MGC138331
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction