Our FHIT FISH Probe is designed to detect FHIT amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
Probe Details
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Gene Details
Gene Symbol: FHIT
Gene Name: Fragile Histidine Triad
Chromosome: CHR3: 59735035-61237133
Locus: 3p14.2