FADD Mouse Monoclonal Antibody [Clone ID: 1A11]
Cat# AM08189SE-N
Size : 50Tests
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| Product Data | |
| Clone Name | 1A11 |
|---|---|
| Application | ELISA, IP, WB |
| Application | ELISA. Immunoprecipitation. Western Blot. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Specificity | This antibody is specific for FADD. |
| Buffer | 2 ml of 100 mM Borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added Label: Sepharose State: Liquid purified Ig fraction. Label: 4B (SEPH) |
| Conjugation | Sepharose |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Store protected from light. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Gene Name | Fas associated via death domain |
| Database Link | |
| Background | Fas-associated death domain (FADD, also known as MORT1) is an important apoptosis adapter molecule involved in the Fas-mediated cell death pathway. FADD associates with the intracellular domain of FAS (CD95/APO-1) through their respective C-terminal death domains (DD). The N-terminal region of FADD contains a death effectors domain (DED) which recruits and binds cytosolic proteins such as FLICE/caspase-8. The subsequent activation of FLICE by proteolytic cleavage leads to the activation of the caspase-mediated (ICE-related proteases) apoptotic cascade. Overexpression of FADD induces apoptosis which is inhibited by CrmA, a specific inhibitor of the interleukin-1a-converting enzyme. FADD has also been shown under certain circumstances to promote cell survival and proliferation. (Ref.1-6) |
| Synonyms | FAS-associated death domain protein, MORT1, GIG3 |
| Note | Shake well before use. |
| Reference Data | |
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