Application
| WB, IF, FC, IP |
|---|---|
| Primary Accession | O55159 |
| Other Accession | 171577 (Rat) |
| Reactivity | Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1 |
| Clone Names | SPM535 |
| Calculated MW | 40-43kDa |
| Gene ID | 171577 |
|---|---|
| Other Names | Epithelial cell adhesion molecule, Ep-CAM, Epithelial glycoprotein 314, EGP314, Protein D5.7A, Tumor-associated calcium signal transducer 1, CD326, Epcam, Tacstd1 |
| Format | Bioreactor Concentrate with 0.05% Azide. Contact us if you require it in a different format. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Ep-CAM / CD326 (Rat) (Epithelial Marker) Antibody - Bioreactor Concentrate is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Epcam |
|---|---|
| Synonyms | Tacstd1 |
| Function | May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). |
| Cellular Location | Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction |
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Provided below are standard protocols that you may find useful for product applications.
Background
Epitope of GZ-1 and GZ-20 monoclonal antibodies are different. EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas.
References
Litvinov SV et. al. J Cell Biol, 1994, 125:437-46. ,2. Tsubura A et. al. J Cut Pathol, 1992, 19:73-9