General Info
| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Dopamine D2 Receptor Positive Control for STJ500708 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:1, 000-1:1, 5000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | DRD2 |
| Gene ID: | 1813 |
| Uniprot ID: | DRD2_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with Dopamine D2 Receptor antibody STJ500708. |
Description
| Tissue Specificity | Isoform 1: Expressed in the anterior pituitary gland. Isoform 2: Expressed in the anterior pituitary gland. |
| Post Translational Modifications | Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. |
| Function | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5. |
| Peptide Name | D(2 Dopamine ReceptorDopamine D2 Receptor |
| Database Links | Reactome: R-HSA-390651 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Peptide Names | D(2 Dopamine Receptor proteinDopamine D2 Receptor proteinDRD2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance