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> D-Glucose [50-99-7]

D-Glucose [50-99-7]

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Cat# HY-B0389-500mg

Size : 500mg

Brand : MedChemExpress

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D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response.

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D-Glucose Chemical Structure

D-Glucose Chemical Structure

CAS No. : 50-99-7

This product is a controlled substance and not for sale in your territory.

Based on 21 publication(s) in Google Scholar

Other Forms of D-Glucose:

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Description

D-Glucose is the naturally occurring form of glucose and the most abundant monosaccharide. D-Glucose is a critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic or abiotic stress response[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

D-Glucose (25-150 mM, 20min) increases the release of 5-Hydroxytryptamine from human BON cells dose-dependently[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Glucose Related Antibodies
In Vivo

D-Glucose (250, 500, 750 mg/kg, i.v., acute administration) protects rats' isletβcells from Alloxan induced diabetes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats (Charles River strain) with alloxan induced diabetes[2]
Dosage: 250, 500, 750 mg/kg
Administration: Intravenous injection (i.v.)
Result: Demonstrated slight to moderate degranulation of isletβcells and only minimal or absent evidence of injury, while β cell necrosis was noted in those receiving only alloxan.
Clinical Trial
Molecular Weight

180.16

Formula

C6H12O6
CAS No.

50-99-7

Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
Structure Classification
  • Saccharides
  • Monosaccharides
Initial Source
  • Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (277.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (555.06 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (394 KB)

COA (247 KB) HNMR (258 KB)

Handling Instructions (2659 KB)
References

  • [1]. Jin Jiaojiao, et al. D-glucose, D-galactose, and D-lactose non-enzyme quantitative and qualitative analysis method based on Cu foam electrode. Food Chem. 2015 May 15;175:485-93.  [Content Brief]

    [2]. Rossini AA, et al. Beta cell protection to alloxan necrosis by anomers of D-glucose. Science. 1974;183(4123):424.  [Content Brief]

    [3]. Kim M, et al. D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology. 2001 Dec;121(6):1400-6.  [Content Brief]

  • [1]. Jin Jiaojiao, et al. D-glucose, D-galactose, and D-lactose non-enzyme quantitative and qualitative analysis method based on Cu foam electrode. Food Chem. 2015 May 15;175:485-93.

    [2]. Rossini AA, et al. Beta cell protection to alloxan necrosis by anomers of D-glucose. Science. 1974;183(4123):424.

    [3]. Kim M, et al. D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology. 2001 Dec;121(6):1400-6.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.5506 mL 27.7531 mL 55.5062 mL 138.7655 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
15 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
20 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
25 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
30 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
40 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
50 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
60 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
80 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Glucose Related Classifications

  • Metabolic Disease Endocrinology Cardiovascular Disease Cancer Others
  • Cancer Metabolism and Metastasis
  • Metabolic Enzyme/Protease
  • Endogenous Metabolite
Help & FAQs

Keywords:

D-Glucose50-99-7Glucose D-(+)-Glucose DextroseEndogenous Metabolitemonosaccharidegeneral metabolismstress responsehBONInhibitorinhibitorinhibit

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