Clevudine [163252-36-6]
Cat# HY-13859-50mg
Size : 50mg
Brand : MedChemExpress
Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice.
For research use only. We do not sell to patients.
Clevudine Chemical Structure
CAS No. : 163252-36-6
This product is a controlled substance and not for sale in your territory.
Description |
Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice[1][2][3]. |
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In Vitro |
Clevudine (L-FMAU) shows some activity against Epstein-Barr virus[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
260.22 |
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Formula |
C10H13FN2O5 |
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CAS No. |
163252-36-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O[C@@H]1[C@@H](F)[C@@H](N2C(NC(C(C)=C2)=O)=O)O[C@H]1CO |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (384.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : ≥ 50 mg/mL (192.15 mM) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.93% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 3.8429 mL | 19.2145 mL | 38.4290 mL | 96.0726 mL |
5 mM | 0.7686 mL | 3.8429 mL | 7.6858 mL | 19.2145 mL | |
10 mM | 0.3843 mL | 1.9215 mL | 3.8429 mL | 9.6073 mL | |
15 mM | 0.2562 mL | 1.2810 mL | 2.5619 mL | 6.4048 mL | |
20 mM | 0.1921 mL | 0.9607 mL | 1.9215 mL | 4.8036 mL | |
25 mM | 0.1537 mL | 0.7686 mL | 1.5372 mL | 3.8429 mL | |
30 mM | 0.1281 mL | 0.6405 mL | 1.2810 mL | 3.2024 mL | |
40 mM | 0.0961 mL | 0.4804 mL | 0.9607 mL | 2.4018 mL | |
50 mM | 0.0769 mL | 0.3843 mL | 0.7686 mL | 1.9215 mL | |
60 mM | 0.0640 mL | 0.3202 mL | 0.6405 mL | 1.6012 mL | |
80 mM | 0.0480 mL | 0.2402 mL | 0.4804 mL | 1.2009 mL | |
100 mM | 0.0384 mL | 0.1921 mL | 0.3843 mL | 0.9607 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Clevudine Related Classifications
- Infection
- Anti-infection Cell Cycle/DNA Damage
- HBV DNA/RNA Synthesis Orthopoxvirus