BMS-986235 [2253947-47-4]
Cat# HY-131180-50mg
Size : 50mg
Brand : MedChemExpress
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure.
For research use only. We do not sell to patients.
BMS-986235 Chemical Structure
CAS No. : 2253947-47-4
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
BMS-986235 (LAR-1219) is a selective, orally active formyl peptide receptor 2 (FPR2) agonist, with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 has potential for the prevention of heart failure[1]. |
IC50 & Target |
EC50: 0.41 nM (human FPR2), 3.4 nM (mouse FPR2), 2800 nM (human FPR1)[1] |
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In Vitro |
BMS-986235 (LAR-1219) inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, key end points to promote resolution of inflammation[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
BMS-986235 (LAR-1219) (0.3 mg/kg; p.o.; daily for 24 days) can attenuate left ventricle and global cardiac remodeling after left anterior descending (LAD) in mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
361.34 |
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Formula |
C18H17F2N3O3 |
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CAS No. |
2253947-47-4 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(NC1=CC=CC=C1)N[C@@H]2C(NC[C@H]2C3=C(F)C=C(OC)C=C3F)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (276.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.48% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.7675 mL | 13.8374 mL | 27.6748 mL | 69.1869 mL |
5 mM | 0.5535 mL | 2.7675 mL | 5.5350 mL | 13.8374 mL | |
10 mM | 0.2767 mL | 1.3837 mL | 2.7675 mL | 6.9187 mL | |
15 mM | 0.1845 mL | 0.9225 mL | 1.8450 mL | 4.6125 mL | |
20 mM | 0.1384 mL | 0.6919 mL | 1.3837 mL | 3.4593 mL | |
25 mM | 0.1107 mL | 0.5535 mL | 1.1070 mL | 2.7675 mL | |
30 mM | 0.0922 mL | 0.4612 mL | 0.9225 mL | 2.3062 mL | |
40 mM | 0.0692 mL | 0.3459 mL | 0.6919 mL | 1.7297 mL | |
50 mM | 0.0553 mL | 0.2767 mL | 0.5535 mL | 1.3837 mL | |
60 mM | 0.0461 mL | 0.2306 mL | 0.4612 mL | 1.1531 mL | |
80 mM | 0.0346 mL | 0.1730 mL | 0.3459 mL | 0.8648 mL | |
100 mM | 0.0277 mL | 0.1384 mL | 0.2767 mL | 0.6919 mL |