• SKU DIA-PX8-OD
    Specificity

    PAX-8 (Paired box protein pax-8)
    Species Reactivity

    Human
    Host Species

    Mouse
    Isotype

    IgG2a
    Clone

    JAX8
    Clonality (Mono-/Polyclonal)

    monoclonal
    Application

    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections), Western Blot
    Conjugation

    unconjugated
    Dilution

    Immunohistochemistry (IHC): 1:100 – 1:400
    Format

    < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
    Intended Use

    for In vitro Diagnostic Use
    Temperature - Storage

    2-8°C
    Temperature - Transport

    cooled
    Manufacturer / Brand

    dianova
    Uniprot_ID

    Q06710
    Gene_ID

    7849
    Alias

    Paired box protein pax-8, PAX-8
  • PAX8 is a member of the paired box (PAX) family of transcription factors involved the regulation of early development of the thyroid gland, kidney, and Mullerian tract. PAX8 plays a central role for the expression of thyroid-specific genes and thus, in development of thyroid follicular cells. Mutations in the PAX-8 gene are linked to thyroid follicular carcinomas. In the developing kidney PAX8 is important for renal vesicle formation.

    PAX8 is highly expressed in several neoplasms: Epithelial tumors of the thyroid and parathyroid glands, kidney, thymus, pancreatic neuroendocrine tumors and female genital tract. Follicular and papillary thyroid carcinoma are almost always PAX8 positive (while medullary thyroid carcinoma is negative, but anaplastic carcinoma is positive in most cases). PAX8 is also found in almost all cases of endometrial carcinoma and ovarian serous, endometrioid, transitional and clear cell carcinoma. Moreover, PAX8 is found in most cases of renal cell carcinoma (all types) and in oncocytoma as well as in thymic tumours. Different reports have shown that adenocarcinomas of lung and breast are negative for PAX8-expression. Also, PAX-8 is not found in the epithelial cells of the breast, lung, mesothelium, stomach, colon, pancreas.

    PAX 8 is a useful IHC marker with a wide range of diagnostic applications and appears to be the most specific and sensitive marker for renal cell carcinoma and ovarian non-mucinous carcinoma