Anti-Human IGF-II (Clone 75015)
Cat# I-650-100
Size : 100µg
Brand : Leinco Technologies
Anti-Human IGF-II (Clone 75015)
Anti-Human IGF-II (Clone 75015)
Product No.: I-650
Clone 75015 Target IGF-II Formats Available Product Type Monoclonal Antibody Alternate Names Insulin-Like Growth Factor II, Somatamedin A, Somatomedin C, C11orf43, FLJ22066, FLJ44734, INSIGF, pp9974 Isotype IgG1 Applications N |
Antibody DetailsProduct DetailsReactive Species Human Host Species Mouse Immunogen Purified Recombinant Human IGF-II (Accession # P01344.1) Endotoxin Level <0.1 EU/µg as determined by the LAL method Formulation This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. Storage and Handling The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months. Country of Origin USA Shipping Next Day Ambient RRID Additional Applications Reported In Literature Neutralization: This antibody is useful for neutralization of Human IGF-II bioactivity. The antibody dose required to neutralize 50% (ND50) of the biological activity of Human IGF-II (at 14 ng/ml) is 10-30 µg/ml. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Mouse Anti-Human insulin-like growth factor II (IGF-II) (Clone 75015) recognizes an epitope on Human IGF-II. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody shows 100% cross-reactivity with rmIGF-II and no cross-reactivity with rhIGF-I or rmIGF-I. Background Insulin-like growth factor 2 (IGF-2) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin.1 IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor. The major role of IGF2 is growth promoting hormone during gestation. IGF-2 has been shown to be an important regulator of fetoplacental growth.2 Antigen DetailsPubMed References & Citations1. Hoeflich, A. et al. (1994) Hormone Research 41: 66 2. Gruslin, A. et al. (2005) The National Acad. of Sci. |