Anti-CD74 antibody (Clone: LN2) {AF647}

Clonality:	Monoclonal
Clone ID:	LN2
Conjugation:	AF647
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	CD74
Gene ID:	972
Uniprot ID:	HG2A_HUMAN

Tissue Specificity	Detected in urine (at protein level). Isoform p41: In B cells, represents 10% of total CD74 expression. Isoform p33: In B cells, represents 70% of total CD74 expression.
Post Translational Modifications	O-glycosylated with core 1 or possibly core 8 glycans. Contains chondroitin sulfate.
Function	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Isoform p41: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.
Protein Name	Hla Class Ii Histocompatibility Antigen Gamma Chain Hla-Dr Antigens-Associated Invariant Chain Ia Antigen-Associated Invariant Chain Ii Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide Clip
Database Links	Reactome: R-HSA-202733 Reactome: R-HSA-2132295
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Endosome Lysosome Secreted Transits Through A Number Of Intracellular Compartments In The Endocytic Pathway It Can Either Undergo Proteolysis Or Reach The Cell Membrane Isoform P41: Late Endosome
Alternative Antibody Names	Anti-Hla Class Ii Histocompatibility Antigen Gamma Chain antibody Anti-Hla-Dr Antigens-Associated Invariant Chain antibody Anti-Ia Antigen-Associated Invariant Chain antibody Anti-Ii antibody Anti-Cd Antigen Cd74 Cleaved Into - Class-Ii-Associated Invariant Chain Peptide antibody Anti-Clip antibody Anti-CD74 antibody Anti-DHLAG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance