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> 24,25-Epoxycholesterol [77058-74-3]

24,25-Epoxycholesterol [77058-74-3]

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Cat# 10-1330-5mg

Size : 5mg

Brand : Focus Biomolecules

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24(S),25-Epoxycholesterol | LXR agonist

CAS:
77058-74-3
Catalog Number:
10-1330
Activity:
LXR agonist
Molecular Weight:
400.65
Molecular Formula:
C27H44O2
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

Available Options

size : Quantity 
1 mg$105.00
5 mg$430.00
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This product is also available in the following library:
Cholesterol Metabolites

24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular cholesterol homeostasis.2 24(S),25-Epoxycholesterol promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells.3 Cell permeable.

References/Citation:

1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126

CAS:
77058-74-3
Catalog Number:
10-1330
Activity:
LXR agonist
Molecular Weight:
400.65
Molecular Formula:
C27H44O2
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular cholesterol homeostasis.2 24(S),25-Epoxycholesterol promotes neural development in zebra fish as well as dopaminergic differentiation of embryonic stem cells.3 Cell permeable.

References/Citation:

1) Chawla et al. (2001), Nuclear receptors and lipid physiology: opening the X-files; Science, 294 1866
2) Brown et al. (2009), 24(S),25-epoxycholesterol: a messenger for cholesterol homeostasis; Int. J. Biochem. Cell Biol., 41 744
3) Theofilopoulos et al. (2013), Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis; Nature Chem. Biol., 9 126