Innovex Biosciences
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INNOVEX Biosciences is developer and manufacturer of an array of innovative and unique Life Sciences products and antibodies that are utilized in IHC, Histopathology, Immunofluorescence, Flow cytometry and Live cell functional assays.
INNOVEX was founded in 1993 to provide innovation and technologies to standardadize and simplify such immunoassays as IHC and IF and make them fast, free of troubleshooting and background.
Innovex has remained true to its original promise of innovation and quality and serves the field with many revolutionary products such as STAT No-wash, No-background IHC STAINING KITS, UNIVERSAL, BACKGROUND-FREE ANIMAL IHC Kit, Fc RECEPTOR BLOCKER, BACKGROUND BUSTER, UNI-TRIEVE (Low temperature Retrieval system) and several permanent mounting media for IHC, IF, H&E and special stains AND that is to name a few.
Website : www.innovexbio.com
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![EGFR probe for ISH CE/IVD - Brain and neural pathology](https://www.biotrend.com/en/upload/24-yyvrcf.png)
EGFR probe for ISH CE/IVD - Brain and neural pathology
The receptor for epidermal growth factor (EGFR) also known as HER1 or ERBB1, is a transmembrane receptor tyrosine kinase of the ERBB family. This is a family of four receptors (ERBB1-4 or HER1-4) with EGFR the best characterized. EGFR is a prime target for cancer therapy across a broad variety of tumor types. Glioblastoma is the most common malignant brain tumor in adults, and among the most lethal of all cancers. Glioblastomas are divided into four subtypes: classical, proneural, mesenchymal and neural. EGFR amplification is enriched in the classical subtype. Amplification of the EGFR gene occurs in 57.4% of primary glioblastoma patients compared to 8% of secondary glioblastoma patients and is associated with high levels of EGFR protein. EGFR deletions in glioblastoma include EGFRvI (N-terminal deletion), vII (deletion of exons 14–15), vIII (deletion of exons 2–7), vIV (deletion of exons 25–27), vV (deletion of exons 25–28), among which vII and vIII are oncogenic.
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RUOCE / IVD
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