ECM Biosciences
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ECM Biosciences is a small biotechnology company based in Versailles, Kentucky, specializing in the production of antibodies for biological research. The founders of ECM Biosciences have more than 20 years experience in the manufacture, distribution and sales of antibodies. The antibodies of ECM Biosciences are used to study the proteins involved in human diseases, such as cancer, immune dysfunction, cardiovascular disease and brain disorders. Website: www.ecmbiosciences.com
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![EGFR probe for ISH CE/IVD - Brain and neural pathology](https://www.biotrend.com/en/upload/24-yyvrcf.png)
EGFR probe for ISH CE/IVD - Brain and neural pathology
The receptor for epidermal growth factor (EGFR) also known as HER1 or ERBB1, is a transmembrane receptor tyrosine kinase of the ERBB family. This is a family of four receptors (ERBB1-4 or HER1-4) with EGFR the best characterized. EGFR is a prime target for cancer therapy across a broad variety of tumor types. Glioblastoma is the most common malignant brain tumor in adults, and among the most lethal of all cancers. Glioblastomas are divided into four subtypes: classical, proneural, mesenchymal and neural. EGFR amplification is enriched in the classical subtype. Amplification of the EGFR gene occurs in 57.4% of primary glioblastoma patients compared to 8% of secondary glioblastoma patients and is associated with high levels of EGFR protein. EGFR deletions in glioblastoma include EGFRvI (N-terminal deletion), vII (deletion of exons 14–15), vIII (deletion of exons 2–7), vIV (deletion of exons 25–27), vV (deletion of exons 25–28), among which vII and vIII are oncogenic.
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