Wistar Hanover rat Plasma
Many of the lines used today originate from this albino 'Wistar' strain created by inbreeding from the species Rattus norvegicus in the Wistar Institute from 1906 for use in biomedical research. This strain of rats was first developed to produce a model organism at a time when laboratories were primarily using the laboratory mouse (Mus musculus).
Plasma is the liquid part of the blood in which the blood cells are suspended. Plasma makes up half of the blood volume. Blood plasma has primarily a transport role. It transports blood cells and hormones throughout the body.
Plasma is extracted from whole blood by centrifugation. During the centrifugation process, the blood cells end up at the bottom of the tube and the yellowish liquid that remains is the plasma. More than 90% of plasma is water. Other components of plasma are mineral solutes such as trace elements and ions, respiratory gases (O2 and CO2) and organic solutes such as plasma proteins.
Thanks to these different components, plasma has 3 main functions: maintenance of blood volume and pressure in the vessels (oncotic pressure) with albumin, coagulation with clotting factors and immune defence with antibodies.
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