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SARS-CoV-2 - Spike protein - Primary antibodies
The SARS-CoV-2 virus, the cause of the current Covid-19 pendemia, can infect human respiratory epithelial cells through an interaction with the human ACE2 receptor or angiotensin converting enzyme receptor 2. SARS-CoV-2 has on its surface a protein called Spike or S protein. This type I transmembrane protein is present on the viral envelope in the form of a homotrimer. Each monomer consists of 2 subunits, S1 and S2. The S1 subunit contains a receptor binding domain (RBD) which binds to the ACE2 receptor on the host membrane. The S2 sub-unit is activated by the bond between S1 and the ACE2 receptor and contains the elements necessary for membrane fusion. The S protein thus plays an important role in the infection of SARS-CoV-2 as well as in the induction of neutralizing antibody and T cell responses and in protective immunity.
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- Unconjugated 1362
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- rabbit 710
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- sars-cov-2 2
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- ELISA 1608
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- DM24 10
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- DM39 9
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- D003 8
- RH-01 8
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- MAbs in vitro: R107 7
- MAbs in vivo: RBD1106 7
- RBD1125 7
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- D005 6
- DM26 6
- DM27 6
- DM35 6
- DM42 6
- 1H2 5
- 5E8 5
- ABM19C9 5
- AM001414 (414-1) 5
- AM002414 (414-2) 5
- AM004414 (414-4) 5
- AM043105 (105-43) 5
- OTI1H6 5
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- R007 5
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- 2146 4
- 2165 4
- 2196 4
- 5E12 4
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- AD10.F6.G3.E3 4
- DM54 4
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- M89079 4
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