Preadipocytes are precursor cells that play a crucial role in the formation of adipocytes, the specialized cells responsible for energy storage in adipose tissue. These cells are present throughout adult life and exhibit specificity based on fat depot locations, differentiating from distinct progenitor cells. The process of adipogenesis, whereby preadipocytes mature into fully functional adipocytes, is complex and involves a series of tightly regulated steps influenced by various signaling pathways and environmental factors.

The differentiation of preadipocytes into mature adipocytes is initiated by hormonal signals and specific transcription factors. Key players in this process include CCAAT/enhancer-binding proteins (C/EBPs) and peroxisome proliferator-activated receptor gamma (PPARγ), which together orchestrate the expression of genes necessary for lipid accumulation and metabolic function. During this transition, preadipocytes undergo significant morphological changes, characterized by the accumulation of intracellular triglycerides.

To support research in this vital area, we offer a comprehensive range of human preadipocyte cell products specifically designed for the investigation of preadipocyte biology and function. Our products include cryopreserved human preadipocytes sourced from both subcutaneous and visceral adipose tissues. These cells are ideal for studying adipogenesis and metabolic pathways related to obesity and diabetes. With our high-quality preadipocyte cells, researchers can explore the mechanisms underlying metabolic health and develop innovative strategies for addressing related diseases effectively.