Common detergents

Detergents are widely used to study the structure and function of membrane proteins by various experimental methods. The list of detergents used in membrane protein studies has expanded in recent years, and more than 50 unique detergents are included. The use of detergents in membrane protein crystallization has been extensively reviewed over the last few decades. Detergents are classified according to their structure and properties, and there are several subcategories within the broader classification of common detergents. These subcategories include Anapoe, Anzergent, Ionic Detergents, MB Reagents, Zwitterrionic detergents and NDSB, each with unique characteristics and applications. Anapoe is a non-ionic detergent that is particularly suitable for proteins sensitive to harsher conditions. Anzergent is another subcategory within non-ionic detergents, characterized by its amphiphilic nature and low critical micelle concentration (CMC) . Ionic Detergents introduce charged moieties into the amphiphilic structure, offering unique advantages in solubilizing membrane proteins with diverse properties. MB Reagents, derived from maltose, offer a compromise between the strong solubilization potential of harsh detergents and the protein-friendly characteristics of milder ones. Zwitterionic detergents carry both positive and negative charges, making them suitable for solubilizing membrane proteins while maintaining a neutral overall charge. NDSB, a non-ionic maltoside detergent, is renowned for its ability to solubilize membrane proteins while maintaining their native structure