Anti-Cytokeratin 18 CE/IVD for IHC - Gastrointestinal pathology
Cytokeratin 18 (CK18) is intermediate filament phosphoglycoprotein that is expressed in simple and glandular and transitional epithelial cells but not in stratified epithelial cells. CK18 is often co-expressed with CK8. CK8 & CK18 is the major keratin pair in simple-type epithelia. Adenocarcinomas originated from simple and glandular epithelium showed CK18 positive staining. In squamous carcinoma, poorly differentiated tumor cells show CK18 reactivity. Loss of CK18 expression is associated with progression of breast carcinoma.
The Cytokeratin 18 antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. Use of this antibody is indicated, subsequent to clinical differential diagnoses of diseases, as an aid in the identification of epithelia within the context of antibody panels, the patient's clinical history and other diagnostic tests evaluated by a qualified pathologist.
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