SARS-COV/SARS-COV-2 Spike (2019-nCoV Coronavirus)

Cat# 544123-50ul

Size : 50ul

Brand : US Biological

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Phone : +1 850 650 7790


544123 SARS-COV/SARS-COV-2 Spike (2019-nCoV Coronavirus) discontinued

Clone Type
Polyclonal
Host
human
Isotype
IgG1
Grade
Affinity Purified
Applications
E
Shipping Temp
Blue Ice
Storage Temp
-20°C

Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of Coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-Coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.||Applications: |Suitable for use in ELISA. Other applications not tested.||Recommended Dilution:|ELISA: 1:5000-1:10,000|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgG1|Clone No: 5D9|Host: human|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS.|Purity: Purified by Protein A affinity chromatography.|Immunogen: Recombinant protein corresponding to 2019-nCoV Spike Protein (RBD).|Specificity: Recognizes SARS-COV2.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Recombinant protein corresponding to 2019-nCoV Spike Protein (RBD).
Form
Supplied as a liquid in PBS.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes SARS-COV2.