SARS-CoV-2 Spike (S1) (COVID-19)

Cat# 544706-50ug

Size : 50ug

Brand : US Biological

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544706 SARS-CoV-2 Spike (S1) (COVID-19)

Clone Type
Polyclonal
Host
human
Source
human
Isotype
IgM,k
Grade
Affinity Purified
Applications
E N
Crossreactivity
Hu
Shipping Temp
Dry Ice
Storage Temp
-20°C

Recombinant monoclonal antibody to SARS-CoV-2 Spike with variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.. Manufactured using a proprietary recombinant platform technology. ||On 31 December 2019, the World Health Organization (WHO) was alerted of an outbreak of pneumonia in Wuhan City, China, caused by an unknown virus. The virus was sequenced and identified as a novel strain of Coronavirus one week later on 7 January 2020. It belongs to the same family of viruses which include Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS). 2019-nCoV is a positive-sense, single-stranded RNA virus which is thought to be of zoonotic origin. Symptoms of those infected include fever, dry cough, fatigue, shortness of breath and respiratory distress. Additionally, cases have resulted in renal failure, pneumonia and death. Those most seriously affected are individuals with already impaired immune systems, however approximately one quarter of otherwise well patients have required intensive care upon hospital admission.|Human-to-human transmission of the virus has been confirmed, with previous Coronavirus outbreaks (such as SARS) originating from similar environments in Asian markets, where humans and live animals are in close proximity.||Applications: |Suitable for use in Surface Plasmon Resonance (SPR), Crystallography, Neutralization and ELISA. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgM,k|Clone No: CR3022 (recomb)|Host: human|Source: human|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS, 0.02% Proclin 300.|Purity: Purified by lectin affinity chromatography.|Immunogen: Peripheral blood lymphocytes of a patient exposed to the SARS-CoV.|Specificity: Recognizes amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein as well as SARS-CoV-2 (COVID-19) Spike protein. Also binds to P462L-substituted S318–510 fragments of the SARS spike protein. The binding epitope is only accessible in the "open" confromation of the spike protein (Joyce et al. 2020).||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Peripheral blood lymphocytes of a patient exposed to the SARS-CoV.
Form
Supplied as a liquid in PBS, 0.02% Proclin 300.
Purity
Purified by lectin affinity chromatography.
Specificity
Recognizes amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein as well as SARS-CoV-2 (COVID-19) Spike protein. Also binds to P462L-substituted S318–510 fragments of the SARS spike protein. The binding epitope is only accessible in the "open" confromation of the spike protein (Joyce et al. 2020).
References
1. ter Meulen et al. Human Monoclonal Antibody Combination against SARS|Coronavirus: Synergy and Coverage of Escape Mutants PLoS Med. 2006 Jul; 3(7): e237 PMID:16796401