SARS-CoV-2 (COVID-19) Nucleoprotein

Cat# 497212-100ug

Size : 100ug

Brand : US Biological

Contact local distributor :


Phone : +1 850 650 7790


497212 SARS-CoV-2 (COVID-19) Nucleoprotein

Clone Type
Polyclonal
Host
rabbit
Swiss Prot
P0DTC9, P59595
Isotype
IgG,k
Grade
Affinity Purified
Applications
E IF
Shipping Temp
Blue Ice
Storage Temp
-20°C

Recombinant monoclonal antibody to SARS-CoV-2 (COVID-19) Nucleoprotein. This is a chimeric rabbit antibody, based on the original human IgG1 format. Manufactured using a proprietary recombinant platform technology. ||The coronavirus nucleocapsid phosphoprotein (N, or nucleoprotein) is highly basic and binds the viral RNA as a dimeric entity into nucleocapsids which protect the viral genome, while also providing access for replication when required. The nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (Fan et al., 2005).||Applications: |Suitable for use in ELISA and Immunofluorescence. Other applications not tested.||Recommended Dilution:|Optimal dilutions to be determined by the researcher.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgG,k|Clone No: CR3018 (recomb)|Host: rabbit|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS, 0.02% Proclin 300.|Purity: Purified by Protein A affinity chromatography.|Immunogen: Whole irradiated virion.|Specificity: Recognizes the amino acid residues between 11-19 of the N protein of the SARS CoV as well as SARS-CoV-2 (COVID-19) nucleocapsid protein.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Whole irradiated virion.
Form
Supplied as a liquid in PBS, 0.02% Proclin 300.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes the amino acid residues between 11-19 of the N protein of the SARS CoV as well as SARS-CoV-2 (COVID-19) nucleocapsid protein.
References
1. Van Den Brink et al. Molecular and Biological Characterization of Human Monoclonal Antibodies Binding to the Spike and Nucleocapsid Proteins of Severe Acute Respiratory Syndrome Coronavirus. Journal of Virology (2005); Vol-79 (3); p. 1635–1644.|2. Fan H, Ooi A, Tan YW, Wang S, Fang S, Liu DX, Lescar J. (2005) The nucleocapsid protein of coronavirus infectious bronchitis virus: crystal structure of its N-terminal domain and multimerization properties. Structure, 13 (12): 1859-68.