Remdesivir-d4
Cat# HY-104077S1-1mg
Size : 1mg
Brand : MedChemExpress
Remdesivir-d4 is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2].
For research use only. We do not sell to patients.
Remdesivir-d4 Chemical Structure
This product is a controlled substance and not for sale in your territory.
Description |
Remdesivir-d4 is deuterium labeled Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells. Remdesivir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro[1][2]. |
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In Vitro |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
Molecular Weight |
606.60 |
Formula |
C27H31D4N6O8P |
Unlabeled CAS |
1809249-37-3 |
SMILES |
O=C(OCC(CC)CC)[C@@](C([2H])([2H])[2H])([2H])N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@](C#N)(C3=CC=C4C(N)=NC=NN43)[C@H](O)[C@@H]2O)=O |
Shipping | Room temperature in continental US; may vary elsewhere. |
Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
Purity & Documentation | |
References |
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Remdesivir-d4 Related Classifications
- Infection
- Cell Cycle/DNA Damage Anti-infection
- DNA/RNA Synthesis SARS-CoV
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Remdesivir-d4GS-5734-d4DNA/RNA SynthesisSARS-CoVSARS coronavirusInhibitorinhibitorinhibit