Size : 2 ug
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| BAFF is a type II membrane protein that functions predominantly as a B cell survival factor and specifically promotes the proliferation and survival of activated B cells by inducing expression of pro-survival oncogenes. BAFF is expressed by T cells, dendritic cells, macrophages and neutrophils. Densitometry of protein isoforms visualised by 2-DE. Spot trains are normal in human proteins and highlight the presence of multiple isoforms which differ according to their level of post-translational modification. The triangle indicates the theoretical MW and pI of the protein. BAFF binds to three different receptors: the transmembrane activator and calcium modulator cyclophilin ligand intercator (TACI), B cell maturation antigen (BCMA) and BAFF receptor (BAFFR). These are expressed on B cells and the BAFFR is also expressed on T cells suggesting BAFF may play a role in T cell activation. |
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