Mouse Monoclonal Anti-Adipophilin / Perilipin-2 (Marker of Obesity) [Clone ADFP/1494]
Cat# NB-36-00077-P0
Size : 20ug
Brand : Neo Biotech
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Adipophilin / Perilipin-2 (Marker of Lipid Accumulation) Antibody [ADFP/1494]
Formalin-fixed, paraffin-embedded human Adrenal stained with Adipophilin Mouse Monoclonal Antibody (ADFP/1494).
SDS-PAGE Analysis Purified Adipophilin Mouse Monoclonal Antibody (ADFP/1494). Confirmation of Integrity and Purity of Antibody.
Applications & Dilutions
Summary
Recognizes a protein of 48kDa, which is identified as Adipophilin. It belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases.
Product Properties & Targets
Functions
- Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.
Key References
- Kern, P.A., et al. 2004. Perilipin expression in human adipose tissue is elevated with obesity. J. Clin. Endocrinol. Metab. 89: 1352-1358
PubMed Links
- https://pubmed.ncbi.nlm.nih.gov/9003395/
- https://pubmed.ncbi.nlm.nih.gov/15489334/
- https://pubmed.ncbi.nlm.nih.gov/21269460/
- https://pubmed.ncbi.nlm.nih.gov/22223895/
- https://pubmed.ncbi.nlm.nih.gov/22814378/
- https://pubmed.ncbi.nlm.nih.gov/23186163/
- https://pubmed.ncbi.nlm.nih.gov/24275569/
- https://pubmed.ncbi.nlm.nih.gov/26357594/
- https://pubmed.ncbi.nlm.nih.gov/34077757/
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