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Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.
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Isolithocholic Acid, CAS 1534-35-6
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1 mL * 10 mM (in DMSO)
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Purity: 99.4%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description
Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.
In vitro
Isolithocholic Acid at a concentration of 0.01% does not inhibit the spore germination and outgrowth in CF5 and M120 strains, but at a higher concentration of 0.1%, it significantly inhibits these processes. At a much lower concentration (0.00003%), it prevents the growth of CD196, M68, CF5, 630, and BI9 strains, while also substantially reducing toxin activity in CF5, BI9, M120, and 630 strains. Furthermore, a slightly higher concentration of Isolithocholic Acid (0.0003%) results in a significant decrease in toxin activity across all strains, with the exception of R20291 and M120[3].
In vivo
Fecal Isolithocholic Acid levels significantly decrease starting from day 28 in the high fat diet (HFD) group when compared to rats on a normal diet[4].
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Chloroform: Slightly soluble
Ethanol: Slightly soluble
Methanol: Slightly soluble
DMSO: 4.4 mg/mL (11.68 mM)
References and Literature
1. Batta, A.K., Salen, G., and Shefer, S.Transformation of bile acids into iso-bile acids by Clostridium perfringes: Possible transport of 3β-hydrogen via the coenzymeHepatology5(6)1126-1131(1985) 2. Borriello, S.P., and Owen, R.W.The metabolism of lithocholic acid and lithocholic acid-3-α-sulfate by human fecal bacteriaLipids17(7)477-482(1982) 3. Thanissery, R., Winston, J.A., and Theriot, C.M.Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acidsAnaerobe4586-100(2017) 4. Lin, H., An, Y., Tang, H., et al.Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat modelJ. Agric. Food Chem.67(13)3624-3632(2019)
Related compound libraries
This product is contained In the following compound libraries:
Natural Product Library for HTS Natural Product Library Gut Microbial Metabolite Library Human Metabolite Library
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL),
Method for preparing in vivo formulation:Take μL DMSO master liquid, next add μL PEG300, mix and clarify, next add μL Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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