Insulin (human) [11061-68-0]

Cat# HY-P0035-100mg

Size : 100mg

Brand : MedChemExpress

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Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus.

For research use only. We do not sell to patients.

Insulin (human) Chemical Structure

Insulin (human) Chemical Structure

CAS No. : 11061-68-0

This product is a controlled substance and not for sale in your territory.

Based on 40 publication(s) in Google Scholar

Other Forms of Insulin (human):

  • Insulin solution (human) Get quote
Description

Insulin (human) is a polypeptide hormone that regulates the level of glucose. Insulin (human) can be used for the diabetes mellitus[1][2].

In Vitro

The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region[1]. Human insulin is commonly used to treat type 2 diabetes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Insulin (human) (0.75 U/kg; ip; once) can significantly reduce blood glucose levels in 15 minutes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Slc35d3-Flox mice and Slc35d3-wild type mice injected with 100 mg/mLl D-Glucose (HY-B0389)[1]
Dosage: 0.75 U/kg
Administration: ip; once
Result: Significantly lowers blood glucose levels.
Molecular Weight

5807.57

Formula

C257H383N65O77S6

CAS No.

11061-68-0

Appearance

Solid

Color

White to off-white

SMILES

[Insulin (human)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (1.72 mM; ultrasonic and adjust pH to 2 with HCl)

1 M Acetic acid : ≥ 10 mg/mL (1.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.1722 mL 0.8609 mL 1.7219 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

The following protocol is derived from the literature and is for reference only. It is recommended to first try a small sample.

  • Protocol 1

    Insulin(human)solution in dilute hydrochloric acid(pH:2~3)is diluted with PBS.(clear)

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.99%

References
  • [1]. Hongrui Wang, et al. SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling. Nat Commun. 2023 Nov 23;14(1):7643.  [Content Brief]

    [2]. Tseng CH, et al. Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes. BMC Cancer. 2015 Nov 4;15:846.  [Content Brief]

  • [1]. Hongrui Wang, et al. SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling. Nat Commun. 2023 Nov 23;14(1):7643.

    [2]. Tseng CH, et al. Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes. BMC Cancer. 2015 Nov 4;15:846.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 1 M Acetic acid 1 mM 0.1722 mL 0.8609 mL 1.7219 mL 4.3047 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Insulin (human) Related Classifications

  • Protein Tyrosine Kinase/RTK
  • Insulin Receptor
Help & FAQs

Keywords:

Insulin (human)11061-68-0Insulin ReceptorInhibitorinhibitorinhibit

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