Application
| WB, IHC-P, IF |
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Primary Accession | P17302 |
Other Accession | 2697 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 43008 Da |
Dilution | IF (1:50 - 1:200), IHC-P (5 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 2697 |
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Other Names | GJA1, Connexin-43, DFNB38, Connexin 43, Gap junction alpha-1 protein, GJAL, HSS, Gap junction protein alpha 1, ODDD, ODD, AVSD3, CX43, HLHS1, ODOD, SDTY3 |
Target/Specificity | Human GJA1 / Connexin 43 |
Reconstitution & Storage | PBS, pH 7.2, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Precautions | GJA1 / CX43 / Connexin 43 Antibody (aa340-390) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GJA1 |
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Synonyms | GJAL |
Function | Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, gap junction. Endoplasmic reticulum {ECO:0000250|UniProtKB:P23242}. Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65. {ECO:0000250|UniProtKB:P23242} |
Tissue Location | Expressed in the heart and fetal cochlea. |