![1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine](https://www.biotrend.com/upload/bandeau3-9pw8hz2z-7wuq4zmd-b664f4-2fqzhc.png)
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
POPE, or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, is a semi-synthetic lipid derived from the conjugation of palmitic and oleic acids with glycerol and ethanolamine. This specific molecular composition imparts distinctive characteristics to POPE, making it a valuable asset in membrane studies, particularly in investigations involving lipid bilayer dynamics, membrane protein interactions, and cellular processes.
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Palmitic and Oleic Acid Derivation: Synthesized from a combination of palmitic and oleic acids, POPE bears a unique blend of saturated and unsaturated acyl chains.
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Glycerol and Ethanolamine Backbone: POPE is structured with a glycerol backbone esterified with palmitic and oleic acids, and a phosphoethanolamine headgroup. This composition contributes to its amphiphilic nature.
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Biophysical Flexibility: The combination of saturated and unsaturated acyl chains imparts biophysical flexibility to POPE, allowing it to exist in various lipid phases.
Applications in Membrane Protein Research:
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Amphiphilic Nature for Membrane Mimicry: POPE's amphiphilic structure allows it to mimic natural lipid bilayers, providing a physiologically relevant environment for studying membrane proteins.
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Biophysical Studies: POPE is widely employed in biophysical studies, serving as a versatile model lipid for investigations into membrane properties, phase behavior, and lipid-protein interactions.
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Cellular Process Exploration: Due to its relevance in cellular membranes, POPE finds applications in understanding cellular processes, contributing to research in cell biology and biochemistry.
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